Description
BIOL122 End of semester worksheet 2
BIOL122
Student name
Student number
Australia Catholic University
Date of Submission
CASE STUDY 1
Question 1/1
Bioavailability (F) = (AUCᵒᵃ /Doseᵒᵃ) × (Doseᵈ / AUCᵈ)
Where;
AUCᵒᵃ = the total amount of medication that is absorbed into the bloodstream after being taken orally over time.
Doseᵒᵃ = the dosage of a drug administered orally.
Doseᵈ = the dosage that is given via this particular route.
AUCᵈ = the cumulative amount of drug exposure in the bloodstream following this various method of administration.
In this case,
- Doseᵒᵃ = 200 mg
- Doseᵈ = 200 mg
The value of AUCᵒᵃ is as follows;
AUCᵒᵃ = Doseᵒᵃ / Fᵒᵃ,
Where; Fᵒᵃ is the proportion of a medicine that is absorbed following oral administration.
The value of Fᵒᵃ = 0.85 (85%)
Thus; AUCᵒᵃ = 200 mg / 0.85 = 235.29 mg*h/L
The value of AUCᵈ is given as follows;
AUCᵈ = Doseᵈ / Fᵈ
Fᵈ = 1
Therefore, AUCᵈ = 200 mg / 1 = 200 mg*h/L
Substitute the values in the bioavailability (F) equation.
F = (235.29 mg*h/L / 200 mg) × (200 mg / 200 mg*h/L) F = 1.176
Hence, the MedG’s bioavailability (F) is 1.176, or 117.6%.
Question 1/2
When both medications are given at once, there may be competitive protein binding. The drug MedA will affect the unbound MedG percentage. MedA is inclined to take up more plasma albumin sites due to its higher affinity, competitively replacing MedG. As a result, there is an increase in the level of unbound MedG in the bloodstream. The unbound part of a medication can enter tissue more readily, connect to receptors, and interact with its target sites. As a result, the greater amount of unbound MedG may have more potent pharmacological characteristics, leading to more unpleasant side effects or stronger therapeutic results. A drug’s therapeutic effects are normally conferred in its unbound form, typically chemically active.
Question 1/3
MedG and MedA have engaged in protein-binding displacement interactions, a form of pharmacological interaction. If MedG is simultaneously eliminated from binding surfaces in the tissues and plasma, the effects observed after displacement from the multiple areas will be compounded. Given the low binding in both locations, the free MedG content in the plasma rises, this makes the displaced drug work more actively. Since displaced medication can usually diffuse out from the plasma compartment, increases in free drug levels are often transient and won’t have a different pharmacological impact on the patient.
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